Description

Mpeg5-Hydrazide CAS NO 1449390-64-0 is a specialized functionalized polyethylene glycol derivative, featuring a terminal hydrazide group that provides a highly reactive handle for conjugation chemistry. This compound is engineered to enable the precise and stable attachment of biomolecules, drugs, or diagnostic agents to PEG chains, thereby enhancing their solubility, stability, and pharmacokinetic profiles. It is an essential building block for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require reliable, high-purity linkers for developing next-generation therapeutics and functional polymers.

Application

• Bioconjugation and Drug Delivery: Used as a key linker for attaching peptides, proteins, antibodies, or small molecule drugs to PEG carriers, creating stable conjugates for targeted therapies.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the site-specific conjugation of cytotoxic payloads to antibodies via its reactive hydrazide moiety, a critical step in ADC manufacturing.
• Polymer Therapeutics and Prodrugs: Serves as a functional monomer or cross-linker in the synthesis of smart polymer-drug conjugates and stimuli-responsive prodrug systems.
• Diagnostic Reagent Preparation: Employed to label antibodies, enzymes, or other biomolecules with fluorescent dyes or contrast agents for in vitro and in vivo diagnostics.
• Surface Functionalization: Used to modify nanoparticles, quantum dots, or medical device surfaces with a hydrophilic PEG layer, improving biocompatibility and providing a platform for further functionalization.
• Hydrogel Formation: Acts as a cross-linking agent in the creation of biocompatible hydrogels for tissue engineering, wound healing, and controlled release applications.
• Research & Development: A valuable tool in academic and industrial R&D for exploring novel conjugation strategies and material science applications.

Basic Information

Product Name	Mpeg5-Hydrazide
CAS No.	1449390-64-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5kDa mPEG-Hydrazide; Methoxy PEG Hydrazide (MW 5000); mPEG5k-NHNH2; Poly(ethylene glycol) methyl ether hydrazide (Mn 5000); α-Methoxy-ω-hydrazido poly(ethylene glycol); PEG Hydrazide, Methyl Ether; Hydrazide-PEG-OMe (5000); mPEG-NHNH2 (5kDa)
EINECS	Contact for details

Quality Control

Our Mpeg5-Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for sensitive bioconjugation and pharmaceutical applications. Key parameters such as molecular weight distribution (PDI), functional group substitution, and impurity profiles are closely monitored. Certificates of Analysis (COA) detailing purity, assay, and spectroscopic identification are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under desiccant or inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and moisture absorption. Allow the sealed container to reach room temperature before opening to prevent condensation. For long-term storage, keep the material frozen at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (Hydrazide Content)	≥ 95%
PEG Molecular Weight (Mn)	5000 ± 500 Da
Polydispersity Index (PDI)	≤ 1.05
Methoxy Substitution	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.