Description

Mpeg5-Nhs CAS NO 1449390-12-8 is a heterobifunctional polyethylene glycol (PEG) derivative featuring an N-hydroxysuccinimide (NHS) ester at one terminus and a methoxy group at the other. This compound is a critical reagent for bioconjugation, enabling the stable and efficient coupling of amine-containing molecules to other functional groups or surfaces. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for applications such as protein modification, drug delivery system development, and surface functionalization.

Application

• Bioconjugation Reagent: For the covalent attachment of peptides, proteins, or antibodies to other biomolecules, nanoparticles, or solid supports via amine-reactive NHS chemistry.
• PEGylation Agent: Used to modify therapeutic proteins and peptides to enhance their solubility, stability, and circulation half-life in the body.
• Drug Delivery System Development: A key building block for creating functionalized linkers in antibody-drug conjugates (ADCs) and other targeted delivery platforms.
• Surface Functionalization: For introducing hydrophilic PEG layers onto biosensor surfaces, microarrays, or medical devices to reduce non-specific binding and improve biocompatibility.
• Crosslinking Agent: In the preparation of hydrogels, polymer networks, and biomaterials requiring specific amine-reactive crosslinks.
• Diagnostic Assay Development: For labeling antibodies or other detection molecules with enzymes, fluorophores, or haptens in immunoassay kits.

Basic Information

Item	Details
Product Name	Mpeg5-Nhs
CAS No.	1449390-12-8
Molecular Formula	C27H49NO13
Molecular Weight	595.68 g/mol
Synonyms	mPEG5-NHS Ester; α-Methoxy-ω-succinimidyl propionate PEG; Methoxy PEG NHS Ester (MW 550); 5k mPEG-NHS; mPEG(5000)-NHS; Succinimidyl ester of monomethoxy polyethylene glycol; NHS-PEG5-OMe; Poly(ethylene glycol) methyl ether N-succinimidyl succinate
EINECS	Contact for details

Quality Control

Our Mpeg5-Nhs is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and end-group analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your research and development documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the NHS ester group is susceptible to hydrolysis. For long-term stability, store under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95%
Molecular Weight (GPC)	5500 ± 550 Da
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, Methylene Chloride; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.