Description

Na€-(2,4-Dimethylphenyl) Vortioxetine is a key pharmaceutical intermediate in the synthesis of the antidepressant vortioxetine. This compound matters for its role in enabling the production of a high-value active pharmaceutical ingredient (API) with a complex molecular structure. It is primarily needed by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on central nervous system (CNS) drug development and generic API production.

Application

• Pharmaceutical Intermediate: Primary building block in the multi-step synthesis of the API Vortioxetine (Brintellix®/Trintellix®).
• Research & Development: Used in process chemistry research for developing new synthetic routes or optimizing existing manufacturing processes for vortioxetine.
• Reference Standard: Serves as a critical reference material for quality control and analytical method development in API production.
• Generic Drug Manufacturing: Essential for companies producing generic versions of vortioxetine after patent expiry, ensuring supply chain security.
• Chemical Synthesis: Utilized in academic and industrial labs studying serotonin receptor modulators and complex heterocyclic chemistry.

Basic Information

Product Name	Na€-(2,4-Dimethylphenyl) Vortioxetine
CAS No.	1446751-00-3
Molecular Formula	C21H24N2OS
Molecular Weight	352.50 g/mol
Synonyms	1-[2-(2,4-Dimethylphenyl)sulfanylphenyl]piperazine; Vortioxetine Intermediate; Vortioxetine Impurity; Vortioxetine Related Compound; Lu AA21004 Intermediate; Brintellix Intermediate; Trintellix Intermediate; 2-((2,4-Dimethylphenyl)thio)phenylpiperazine
EINECS	Contact for details

Quality Control

Our Na€-(2,4-Dimethylphenyl) Vortioxetine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, and NMR to ensure high purity and consistency suitable for pharmaceutical synthesis. We provide full traceability and Certificates of Analysis (COA) compliant with cGMP standards for API intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.