Description

(1S,1As,6Br)-5-((7-Oxo-5,6,7,8-Tetrahydro-1,8-Naphthyridin-4-Yl)Oxy)-1A,6B-Dihydro-1H-Cyclopropa[B]Benzofuran-1-Carboxylic Acid CAS NO 1446091-46-8 is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused-ring structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for targeting complex disease pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Employed in the process development and scale-up of new chemical entities (NCEs) requiring its specific bicyclic framework.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of complex molecules for clinical trials.
• Biochemical Research: Potential use as a tool compound or probe for investigating specific biological targets and enzymatic pathways.

Basic Information

Product Name	(1S,1As,6Br)-5-((7-Oxo-5,6,7,8-Tetrahydro-1,8-Naphthyridin-4-Yl)Oxy)-1A,6B-Dihydro-1H-Cyclopropa[B]Benzofuran-1-Carboxylic Acid
CAS No.	1446091-46-8
Molecular Formula	C19H15BrN2O5
Molecular Weight	431.24 g/mol
Synonyms	5-[(7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-carboxylic acid; (1S,1aR,6bS)-5-[(7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-carboxylic acid; 1H-Cyclopropa[b]benzofuran-1-carboxylic acid, 1a,6b-dihydro-5-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-, (1S,1aR,6bS)-; BRD-K4477 (common research code); Advanced naphthyridine-benzofuran intermediate.
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Quality Control

Our (1S,1As,6Br)-5-((7-Oxo-5,6,7,8-Tetrahydro-1,8-Naphthyridin-4-Yl)Oxy)-1A,6B-Dihydro-1H-Cyclopropa[B]Benzofuran-1-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity by HPLC, related substances, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.