Description

trans-tert-Butyl 3-Benzyl-4-Hydroxypiperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold with distinct benzyl and protected hydroxyl functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular therapeutic areas. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug discovery and process development.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of complex pharmaceutical molecules, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved efficacy and safety profiles.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Precursor for Chiral Compounds: The defined stereochemistry makes it a valuable starting material for synthesizing enantiomerically pure substances.
• Library Synthesis for High-Throughput Screening: Utilized to create focused chemical libraries for biological testing against novel targets.

Basic Information

Product Name	trans-tert-Butyl 3-Benzyl-4-Hydroxypiperidine-1-Carboxylate
CAS No.	1445951-69-8
Molecular Formula	C17H25NO3
Molecular Weight	291.39 g/mol
Synonyms	1-Boc-3-benzyl-4-hydroxypiperidine (trans); tert-Butyl 3-benzyl-4-hydroxypiperidine-1-carboxylate; 4-Hydroxy-3-benzylpiperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-benzyl-4-hydroxypiperidine; 3-Benzyl-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; trans-1-Boc-3-benzyl-4-hydroxypiperidine; (3R,4S)- and (3S,4R)-1-Boc-3-benzyl-4-hydroxypiperidine (racemic mixture)
EINECS	Contact for details

Quality Control

Our trans-tert-Butyl 3-Benzyl-4-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.