Description

Benzyl-Peg4-Ch2Co2Tbu CAS NO 1443467-88-6 is a specialized bifunctional PEG derivative featuring a benzyl-protected carboxylic acid and a tert-butyl ester group. This compound is a crucial intermediate in the synthesis of complex molecules, offering controlled conjugation and solubility enhancement. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing targeted drug delivery systems, diagnostic agents, and functional polymers.

Application

• Pharmaceutical Linker: A key building block for creating antibody-drug conjugates (ADCs) and peptide-drug conjugates, enabling precise drug attachment.
• Bioconjugation Reagent: Used to modify proteins, peptides, and oligonucleotides to improve their pharmacokinetic properties, such as solubility and circulation half-life.
• Polymer Chemistry: Serves as a functional monomer or cross-linker in the synthesis of smart hydrogels and biocompatible polymers for medical devices.
• Prodrug Synthesis: Employed in the design of prodrugs where the PEG spacer facilitates controlled release of the active pharmaceutical ingredient (API).
• Diagnostic Agent Development: Integral for attaching imaging moieties (e.g., fluorophores, radionuclides) to targeting vectors in contrast agents.
• Surface Functionalization: Used to modify nanoparticles and other material surfaces to introduce specific chemical handles for further coupling.

Basic Information

Product Name	Benzyl-Peg4-Ch2Co2Tbu
CAS No.	1443467-88-6
Molecular Formula	C24H40O8
Molecular Weight	456.57 g/mol
Synonyms	1-Benzyl-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester; 15-(tert-Butoxy)-3,6,9,12-tetraoxa-15-oxopentadec-1-ylbenzene; Benzyl-PEG4-t-butyl ester; Benzyl tetraethylene glycol t-butyl ester; Benzyl-PEG4-CH2CO2tBu; 2-[2-[2-[2-(Benzyloxy)ethoxy]ethoxy]ethoxy]acetic acid tert-butyl ester; tert-Butyl 2-[2-[2-[2-(benzyloxy)ethoxy]ethoxy]ethoxy]acetate
EINECS	Contact for details

Quality Control

Every batch of Benzyl-Peg4-Ch2Co2Tbu is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products meet high-purity standards suitable for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results from NMR, HPLC, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.