Description

3-Difluoromethyl-Pyrazine-2-Carboxylic Acid is a high-value, fluorinated pyrazine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the introduction of a difluoromethyl group onto a pyrazine scaffold. It is primarily utilized by pharmaceutical and agrochemical R&D teams for creating novel active ingredients, particularly in the search for new drugs and crop protection agents with optimized properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as electronic or luminescent compounds.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic and Industrial R&D: Used in research laboratories for exploring new chemical reactions and building complex molecular architectures.

Basic Information

Product Name	3-Difluoromethyl-Pyrazine-2-Carboxylic Acid
CAS No.	1443287-46-4
Molecular Formula	C7H4F2N2O2
Molecular Weight	186.12 g/mol
Synonyms	2-Pyrazinecarboxylic acid, 3-(difluoromethyl)-; 3-(Difluoromethyl)pyrazine-2-carboxylic acid; Difluoromethyl-pyrazinecarboxylic acid; 1443287-46-4; 3-Difluoromethyl-2-pyrazinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Difluoromethyl-Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.