Description

1-(4-Ethynylphenyl)Sulfonylpiperazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfonylpiperazine scaffold linked to an ethynylphenyl moiety. This compound is of significant value in modern medicinal chemistry for the development of targeted small-molecule therapeutics, particularly as a key building block for kinase inhibitors and other bioactive molecules. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used as a versatile building block for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Bioconjugation & Probe Development: The terminal alkyne group enables click chemistry reactions, making it suitable for creating fluorescent probes or affinity tags for biochemical studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of active pharmaceutical ingredients (APIs) under development.
• Academic Research: Employed in university and institutional labs for fundamental research in organic synthesis and chemical biology.

Basic Information

Product Name	1-(4-Ethynylphenyl)Sulfonylpiperazine Hydrochloride
CAS No.	1439818-89-9
Molecular Formula	C12H13N2O2S • HCl
Molecular Weight	284.77 g/mol (Free base: 249.31 g/mol)
Synonyms	1-[(4-Ethynylphenyl)sulfonyl]piperazine hydrochloride; 4-(Piperazine-1-sulfonyl)phenylacetylene hydrochloride; 1-(4-Ethynylbenzenesulfonyl)piperazine HCl; 4-Ethynylbenzenesulfonylpiperazine hydrochloride; 1439818-89-9; Piperazine, 1-[(4-ethynylphenyl)sulfonyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 1-(4-Ethynylphenyl)Sulfonylpiperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom purity grades (e.g., >98%, >99%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a desiccator to prevent degradation. Keep the container tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.