Description

(3S,4S)-tert-Butyl 3-Amino-4-Methylpiperidine-1-Carboxylate is a high-purity, stereochemically defined piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold for constructing complex molecules with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients where stereochemistry is paramount for efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) drugs, protease inhibitors, and other therapeutics requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the chiral center can influence biological activity and environmental selectivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity in chemical reactions.
• Chemical Biology & Proteomics: Employed as a building block for activity-based probes and molecular tags to study enzyme function and protein interactions.
• Peptidomimetics & Constrained Peptides: Incorporated into peptide backbones to introduce conformational restraint, enhancing metabolic stability and binding affinity for drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Product Name	(3S,4S)-tert-Butyl 3-Amino-4-Methylpiperidine-1-Carboxylate
CAS No.	1434126-96-1
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-3-amino-4-methylpiperidine (stereo unspecified); tert-Butyl 3-amino-4-methylpiperidine-1-carboxylate (3S,4S)-isomer; (3S,4S)-1-N-Boc-3-amino-4-methylpiperidine; 1-(tert-Butoxycarbonyl)-3-amino-4-methylpiperidine (S,S)-form; Boc-3-Amino-4-methylpiperidine (S,S); (3S,4S)-4-Methyl-3-aminopiperidine-1-carboxylic acid tert-butyl ester; (3S,4S)-3-Amino-4-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (3S,4S)-tert-Butyl 3-Amino-4-Methylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity, ensuring compliance with research and development standards. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.