Description

cis-tert-Butyl 4-Amino-2-Methylpiperidine-1-Carboxylate is a high-purity, protected piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a sterically hindered, Boc-protected amino group on a methyl-substituted piperidine scaffold, enabling precise control over stereochemistry and reactivity in complex molecule assembly. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, antiviral agents, and other therapeutic areas.
• Agrochemical Research: Used in constructing novel pesticide and herbicide molecules where the specific stereochemistry of the piperidine ring influences biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enhancing enantioselectivity in critical bond-forming reactions.
• Peptidomimetics and Bioactive Molecule Design: The protected amino piperidine structure is integral to creating conformationally constrained peptide analogs and other bioactive scaffolds.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects from milligram to kilogram scale.
• Academic and R&D Laboratories: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	cis-tert-Butyl 4-Amino-2-Methylpiperidine-1-Carboxylate
CAS No.	1434073-24-1
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-4-amino-2-methylpiperidine (cis); cis-1-(tert-Butoxycarbonyl)-4-amino-2-methylpiperidine; cis-N-Boc-4-amino-2-methylpiperidine; cis-2-Methyl-4-aminopiperidine-1-carboxylic acid tert-butyl ester; 4-Amino-2-methylpiperidine-1-carboxylic acid tert-butyl ester (cis); cis-4-Amino-2-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; cis-tert-Butyl 4-amino-2-methyl-1-piperidinecarboxylate; (cis)-tert-Butyl 4-amino-2-methylpiperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our cis-tert-Butyl 4-Amino-2-Methylpiperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. We provide comprehensive analytical data, including chiral purity confirmation, to support regulatory filings. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% cis-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.