Description

4-Chloro-2-(7,7-Dimethyl-1-Oxo-3,4,7,8-Tetrahydro-1H-Cyclopenta[4,5]Pyrrolo[1,2-A]Pyrazin-2(6H)-Yl)Nicotinaldehyde is a high-purity, advanced pharmaceutical intermediate featuring a complex fused heterocyclic structure. This compound is critical for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting oncology, CNS disorders, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic research.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Bioconjugation & Probe Development: The aldehyde functional group enables its use in conjugation chemistry for developing diagnostic probes or targeted drug delivery systems.
• Chemical Biology Studies: Employed in the design and synthesis of chemical tools to study protein function and biological pathways.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes during process research and development (PR&D) for active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Used in universities and research institutes for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	4-Chloro-2-(7,7-Dimethyl-1-Oxo-3,4,7,8-Tetrahydro-1H-Cyclopenta[4,5]Pyrrolo[1,2-A]Pyrazin-2(6H)-Yl)Nicotinaldehyde
CAS No.	1434050-55-1
Molecular Formula	C18H18ClN3O2
Molecular Weight	343.81 g/mol
Synonyms	4-Chloro-2-[(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)]nicotinaldehyde; 4-Chloro-2-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)pyridine-3-carbaldehyde; 4-Chloro-2-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)nicotinaldehyde; CAS 1434050-55-1
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-(7,7-Dimethyl-1-Oxo-3,4,7,8-Tetrahydro-1H-Cyclopenta[4,5]Pyrrolo[1,2-A]Pyrazin-2(6H)-Yl)Nicotinaldehyde is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and spectral data (NMR, HPLC, MS) is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.