Description

(3R,5R)-3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, stereochemically defined piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected amino-hydroxy-piperidine scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by pharmaceutical and biotechnology R&D teams for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially protease inhibitors and receptor modulators.
• Peptidomimetic Chemistry: Used to construct constrained peptide analogs and macrocyclic compounds by incorporating the rigid piperidine core.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds and molecular probes to study enzyme function and biological pathways.
• Asymmetric Catalysis Ligand Precursor: The chiral amino and hydroxy groups can be functionalized to create novel ligands for asymmetric synthesis.
• API Development for CNS Disorders: Integral in research programs for neurological and psychiatric conditions due to the pharmacophore relevance of the piperidine moiety.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for scale-up and GMP production of clinical trial materials.

Basic Information

Product Name	(3R,5R)-3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1433178-03-0
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	tert-Butyl (3R,5R)-3-amino-5-hydroxypiperidine-1-carboxylate; 1-Boc-3R-amino-5R-hydroxy-piperidine; (3R,5R)-1-N-Boc-3-amino-5-hydroxypiperidine; (3R,5R)-3-Amino-5-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3R-amino-5R-hydroxypiperidine; (3R,5R)-3-Amino-5-piperidinol, 1-Boc protected; (3R,5R)-1-Boc-3-amino-5-hydroxypiperidine; (3R,5R)-3-Amino-5-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (3R,5R)-3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess and standard pharmacopeial methods for purity and identity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.