Description

1-(2,4-Dichlorophenyl)-n-1-Piperidinyl-4-[[(1-Pyrrolidinylsulfonyl)Amino]Methyl]-5-[5-[2-[4-(Trifluoromethyl)Phenyl]Ethynyl]-2-Thienyl]-1H-Pyrazole-3-Carboxamide is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its complex heterocyclic structure, which is critical for imparting specific biological activity in the synthesis of novel antiviral agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of next-generation therapeutics targeting viral infections.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral drug discovery programs.
• Biochemical Research: Used as a reference standard and active probe in virology and enzymology studies to investigate mechanisms of viral replication inhibition.
• Preclinical Development: Employed in the formulation and testing of candidate drug compounds during early-stage pharmacological and toxicological evaluations.
• Custom Synthesis: A critical starting material for contract research organizations (CROs) and CDMOs specializing in the custom manufacture of complex, target-specific small molecules.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs) with antiviral indications.

Basic Information

Product Name	1-(2,4-Dichlorophenyl)-n-1-Piperidinyl-4-[[(1-Pyrrolidinylsulfonyl)Amino]Methyl]-5-[5-[2-[4-(Trifluoromethyl)Phenyl]Ethynyl]-2-Thienyl]-1H-Pyrazole-3-Carboxamide
CAS No.	1429239-98-4
Molecular Formula	C₃₄H₂₉Cl₂F₃N₆O₃S₂
Molecular Weight	749.66 g/mol
Synonyms	1-(2,4-Dichlorophenyl)-4-({[(pyrrolidin-1-yl)sulfonyl]amino}methyl)-5-{5-[2-(4-(trifluoromethyl)phenyl)ethynyl]thiophen-2-yl}-1-(piperidin-1-yl)-1H-pyrazole-3-carboxamide; GSK-126; GSK126; GSK 126; (Research Code); NNRTI Intermediate; 1-(2,4-Dichlorophenyl)-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-N-(1-piperidinyl)-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-1H-pyrazole-3-carboxamide
EINECS	Contact for details

Quality Control

Our production of 1-(2,4-Dichlorophenyl)-n-1-Piperidinyl-4-[[(1-Pyrrolidinylsulfonyl)Amino]Methyl]-5-[5-[2-[4-(Trifluoromethyl)Phenyl]Ethynyl]-2-Thienyl]-1H-Pyrazole-3-Carboxamide adheres to stringent quality management systems, ensuring batch-to-batch consistency for research and development applications. All material is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Comprehensive Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided with each shipment to support regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is light-sensitive and should be handled under inert atmosphere when appropriate to ensure long-term stability. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.