Description

(7S,8Ar)-Octahydropyrrolo[1,2-A]Piperazin-7-Ol is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined fused bicyclic structure. This compound is of significant value for its role as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of complex small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of proprietary drug candidates, enabling the construction of complex molecular architectures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities, particularly for neurological targets.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient and cost-effective production of target APIs under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to introduce stereochemical complexity.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control during drug development and manufacturing.

Basic Information

Product Name	(7S,8Ar)-Octahydropyrrolo[1,2-A]Piperazin-7-Ol
CAS No.	1429200-47-4
Molecular Formula	C7H14N2O
Molecular Weight	142.20 g/mol
Synonyms	(7S,8aR)-Octahydropyrrolo[1,2-a]pyrazin-7-ol; (7S,8aR)-Hexahydro-1H-pyrrolo[1,2-a]pyrazin-7-ol; Pyrrolo[1,2-a]piperazin-7-ol, octahydro-, (7S,8aR)-; (7S,8aR)-Octahydro-1H-pyrrolo[1,2-a]pyrazin-7-ol; (7S,8aR)-Octahydropyrrolo[1,2-a]pyrazin-7-ol; Stereoisomer of Octahydropyrrolo[1,2-a]piperazin-7-ol
EINECS	Contact for details

Quality Control

Our (7S,8Ar)-Octahydropyrrolo[1,2-A]Piperazin-7-Ol is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH Q7 guidelines for pharmaceutical intermediates, and our analytical methods are validated to ensure accurate and reliable results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.