Description

(2R,5R)-Di-tert-Butyl 2-(Hydroxymethyl)-5-Methylpiperazine-1,4-Dicarboxylate is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold for constructing complex molecules with high enantiomeric purity. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system or as protease inhibitors.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereocenters with high fidelity.
• Peptidomimetic Research: Serves as a constrained, non-natural amino acid backbone for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Ligand and Catalyst Development: Acts as a starting material for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function and protein-protein interactions due to its defined stereochemistry and functional handles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	(2R,5R)-Di-tert-Butyl 2-(Hydroxymethyl)-5-Methylpiperazine-1,4-Dicarboxylate
CAS No.	1427561-80-5
Molecular Formula	C16H30N2O5
Molecular Weight	330.42 g/mol
Synonyms	(2R,5R)-1,4-Di-tert-butyl 2-(hydroxymethyl)-5-methylpiperazine-1,4-dicarboxylate; (2R,5R)-1,4-Bis(tert-butoxycarbonyl)-2-(hydroxymethyl)-5-methylpiperazine; (2R,5R)-2-(Hydroxymethyl)-5-methylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester; Boc-(R)-HMmp(Boc)-OH (common abbreviation); (R,R)-Di-Boc-hydroxymethyl-methylpiperazine; 1,4-Di-Boc-2-(hydroxymethyl)-5-methyl-(2R,5R)-piperazine; Chiral Boc-protected piperazine derivative
EINECS	Contact for details

Quality Control

Every batch of (2R,5R)-Di-tert-Butyl 2-(Hydroxymethyl)-5-Methylpiperazine-1,4-Dicarboxylate is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is soluble in strong acid/organic solvent; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.