Description

(S)-1,1-Dimethyltetrahydro-1H-Oxazolo[3,4-A]Pyrazin-3(5H)-One Hcl is a high-purity chiral building block and pharmaceutical intermediate of significant interest in modern synthetic chemistry. Its value lies in its rigid, fused bicyclic structure, which serves as a key scaffold for constructing complex molecules with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel active pharmaceutical ingredients (APIs) and investigating new therapeutic modalities.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Used as a building block to introduce stereochemical complexity in the preparation of enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its constrained conformation.
• Peptidomimetic Development: Acts as a conformationally restricted surrogate for amino acids or dipeptides in the design of protease inhibitors or receptor ligands.
• Chemical Biology Probes: Utilized in the development of tool compounds and molecular probes for studying biological pathways.
• Process Chemistry & Scale-Up: Suitable for development from laboratory-scale research to pilot and commercial-scale GMP manufacturing.

Basic Information

Product Name	(S)-1,1-Dimethyltetrahydro-1H-Oxazolo[3,4-A]Pyrazin-3(5H)-One Hydrochloride
CAS No.	1427514-85-9
Molecular Formula	C9H17N3O2 • HCl
Molecular Weight	235.71 g/mol (Free base: 199.25 g/mol)
Synonyms	(S)-1,1-Dimethyl-1,4,6,7-tetrahydrooxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride; (S)-1,1-Dimethyltetrahydrooxazolo[3,4-a]pyrazin-3(5H)-one HCl; (S)-1,1-Dimethyl-1H,4H,5H,6H,7H-oxazolo[3,4-a]pyrazin-3-one hydrochloride; (S)-Oxazolo[3,4-a]pyrazin-3(5H)-one, 1,1-dimethyltetrahydro-, hydrochloride (1:1); (S)-1,1-DMTS-HCl; Chiral Oxazolopyrazinone HCl Salt; 1427514-85-9
EINECS	Contact for details

Quality Control

Our (S)-1,1-Dimethyltetrahydro-1H-Oxazolo[3,4-A]Pyrazin-3(5H)-One Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.