Description

(R)-2-Trifluoromethyl-Piperazine Dihydrochloride CAS NO 1427203-56-2 is a high-value, chiral piperazine derivative of significant importance in modern pharmaceutical research and development. Its core value lies in its role as a critical chiral building block and intermediate for synthesizing novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug discovery. This compound is essential for medicinal chemists and process development scientists in pharmaceutical companies and advanced contract research organizations (CROs) who require high-purity, enantiomerically pure intermediates to accelerate their R&D pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in CNS and psychiatric disorder research.
• Active Pharmaceutical Ingredient (API) Development: Serves as a crucial building block in the construction of complex molecular architectures for new chemical entities (NCEs).
• Medicinal Chemistry & Drug Discovery: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its trifluoromethyl and piperazine pharmacophores.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of enantiomerically pure pharmaceuticals.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in catalytic asymmetric reactions to introduce stereocenters.
• Biochemical Research: Acts as a ligand or modulator in the study of various biological targets and receptors.

Basic Information

Product Name	(R)-2-Trifluoromethyl-Piperazine Dihydrochloride
CAS No.	1427203-56-2
Molecular Formula	C5H10F3N2 • 2HCl
Molecular Weight	247.07 g/mol (Free base: 154.14 g/mol)
Synonyms	(R)-2-(Trifluoromethyl)piperazine dihydrochloride; (R)-2-Trifluoromethylpiperazine dihydrochloride; (R)-α-Trifluoromethylpiperazine dihydrochloride; (R)-Tfm-Piperazine 2HCl; (2R)-2-(Trifluoromethyl)piperazine dihydrochloride; (R)-1,4-Diazacyclohexane-2-trifluoromethyl dihydrochloride; (R)-Hexahydropyrazine-2-trifluoromethyl dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-Trifluoromethyl-Piperazine Dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.