Description

[1-({(5R)-2-[4-(5-Chloropyrimidin-2-Yl)Piperidin-1-Yl]-5-Oxido-6,7-Dihydrothieno[3,2-D]Pyrimidin-4-Yl}Amino)Cyclobutyl]Methanol is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly kinase inhibitors. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its complex pyrimidine-thienopyrimidine core.
• Biochemical Tool Compound: Serves as a reference standard or a precursor for developing biochemical probes to study specific enzymatic pathways.
• Preclinical Drug Development: Employed in the scale-up synthesis of candidate drug molecules for preclinical testing and formulation studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in chemical biology and drug discovery.

Basic Information

Product Name	[1-({(5R)-2-[4-(5-Chloropyrimidin-2-Yl)Piperidin-1-Yl]-5-Oxido-6,7-Dihydrothieno[3,2-D]Pyrimidin-4-Yl}Amino)Cyclobutyl]Methanol
CAS No.	1423719-30-5
Molecular Formula	C20H23ClN6O2S
Molecular Weight	446.96 g/mol
Synonyms	(1-{[(5R)-2-[4-(5-Chloropyrimidin-2-yl)piperidin-1-yl]-5-oxido-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]amino}cyclobutyl)methanol; (1-(((5R)-2-(4-(5-Chloropyrimidin-2-yl)piperidin-1-yl)-5-oxido-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)amino)cyclobutyl)methanol; UNII-6G6W9G6K8I; 6G6W9G6K8I; 1-({(5R)-2-[4-(5-Chloropyrimidin-2-yl)piperidin-1-yl]-5-oxido-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl}amino)cyclobutylmethanol; 1423719-30-5; Cyclobutylmethanol derivative of thienopyrimidine
EINECS	Contact for details

Quality Control

Our [1-({(5R)-2-[4-(5-Chloropyrimidin-2-Yl)Piperidin-1-Yl]-5-Oxido-6,7-Dihydrothieno[3,2-D]Pyrimidin-4-Yl}Amino)Cyclobutyl]Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or regulatory requirements for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.