Description

Methyl 2-Bromo-5H-Pyrrolo[2,3-B]Pyrazine-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its brominated pyrrolopyrazine core structure. This compound is of significant value for enabling complex molecular transformations in synthetic chemistry, serving as a critical building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and biotechnology sectors engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for potential therapeutic agents.
• Drug Discovery & Medicinal Chemistry: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in oncology, CNS, and other disease areas.
• Agrochemical Research: Serves as a building block for developing novel crop protection agents and pesticides.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the construction of linker molecules and warheads for targeted protein degradation platforms.
• Organic Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and other metal-catalyzed transformations to introduce functional complexity.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting fundamental research in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	Methyl 2-Bromo-5H-Pyrrolo[2,3-B]Pyrazine-7-Carboxylate
CAS No.	1422772-79-9
Molecular Formula	C8H6BrN3O2
Molecular Weight	256.06 g/mol
Synonyms	2-Bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid methyl ester; Methyl 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylate; 7-Methoxycarbonyl-2-bromo-5H-pyrrolo[2,3-b]pyrazine; 2-Bromo-7-(methoxycarbonyl)-5H-pyrrolo[2,3-b]pyrazine; 2-Bromo-5H-pyrrolo[2,3-b]pyrazine-7-methyl carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromo-5H-Pyrrolo[2,3-B]Pyrazine-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.