Description

1-(2,2,2-Trifluoroethyl)Piperazine-2,6-Dione Hydrochloride (Wx604656) is a high-purity, fluorinated piperazine-dione derivative hydrochloride salt, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a trifluoroethyl-substituted heterocyclic scaffold, enabling the modulation of pharmacokinetic properties such as metabolic stability and lipophilicity in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used as a fluorinated building block in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoroethyl group can enhance biological activity.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Peptidomimetic Chemistry: The piperazine-2,6-dione (diketopiperazine) core is a privileged structure in medicinal chemistry for creating conformationally constrained peptide analogs.
• Material Science Precursor: Potential use as a monomer or specialty additive in the development of advanced polymers with unique fluorinated properties.

Basic Information

Product Name	1-(2,2,2-Trifluoroethyl)Piperazine-2,6-Dione Hydrochloride (Wx604656)
CAS No.	1422344-02-2
Molecular Formula	C7H10ClF3N2O2
Molecular Weight	246.61 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-2,6-piperazinedione hydrochloride; 1-(2,2,2-Trifluoroethyl)piperazine-2,6-dione HCl; 2,6-Diketopiperazine, 1-(2,2,2-trifluoroethyl)-, hydrochloride; WX-604656; Wx604656; (2,2,2-Trifluoroethyl)diketopiperazine hydrochloride; 1-Trifluoroethyldiketopiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoroethyl)Piperazine-2,6-Dione Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure compliance with exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.