Description

1-Cyclopropyl-2,6-Piperazinedione Hydrochloride (Wx604658) is a high-purity, non-natural amino acid derivative and a key pharmaceutical intermediate. This compound matters for its role as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of targeted therapeutics. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in oncology and neurology research.
• Protease Inhibitor Research: Used in the development of enzyme inhibitors due to its piperazinedione core structure.
• Peptidomimetic Chemistry: Serves as a constrained scaffold in the design of peptide mimics to improve metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.
• Academic & Contract Research: Utilized in universities and CROs for exploratory synthetic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Cyclopropyl-2,6-Piperazinedione Hydrochloride (Wx604658)
CAS No.	1422343-99-4
Molecular Formula	C7H11N2O2•HCl
Molecular Weight	200.64 g/mol
Synonyms	1-Cyclopropylpiperazine-2,6-dione hydrochloride; Cyclopropyl-Diketopiperazine HCl; 2,6-Diketopiperazine, 1-cyclopropyl-, hydrochloride; WX-604658; Wx604658; (3aS,6aR)-1-Cyclopropylhexahydropyrrolo[3,4-b]pyrrole-5,7-dione hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-2,6-Piperazinedione Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.