Description

Propargyl-Peg13-Acid is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a carboxylic acid. This compound is a critical building block in bioconjugation and materials science, enabling site-specific modifications via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise, stable, and reproducible linker molecules for drug delivery systems, surface functionalization, and polymer synthesis.

Application

• Bioconjugation & ADC Development: Serves as a key linker for attaching cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides to create antibody-drug conjugates (ADCs) and diagnostic probes.
• PEGylation & Drug Delivery: Used to introduce PEG chains onto therapeutic molecules (PEGylation) to improve solubility, prolong circulation half-life, and reduce immunogenicity.
• Surface Modification & Hydrogel Synthesis: Functionalizes nanoparticles, biosensors, and medical device surfaces to create biocompatible interfaces or cross-linkable networks for hydrogel formation.
• Polymer Chemistry: Acts as a versatile monomer or macromonomer for synthesizing functionalized, water-soluble polymers with clickable handles for further modification.
• Diagnostic Reagents: Utilized in the development of diagnostic assays and imaging agents where stable, covalent attachment of signaling molecules is required.
• Material Science: Enables the creation of smart materials and functional coatings with tailored properties through controlled chemical grafting.

Basic Information

Product Name	Propargyl-Peg13-Acid
CAS No.	1421676-62-1
Molecular Formula	C31H58O16
Molecular Weight	662.8 g/mol
Synonyms	Propargyl-PEG13-Acid; α-Propargyl-ω-carboxy-tridecaethylene glycol; 2,5,8,11,14,17,20,23,26,29,32,35,38-Tridecaoxatetracont-39-yn-41-oic acid; Propargyl-PEG13-COOH; Propargyl-PEG13-Propionic Acid; Propargyl-PEG13-CH2CH2COOH; Propargyl-O-(CH2CH2O)13-CH2CH2COOH; Heterobifunctional PEG Alkyne-Acid
EINECS	Contact for details

Quality Control

Our Propargyl-Peg13-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and GMP-grade applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and functional group integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Under these conditions, the product is stable for at least 24 months. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Acid Value (Titration)	Contact for details
Water Content (KF)	≤ 1.0%
Functional Group Integrity	≥ 90% (by NMR)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.