Description

2-Methyl-3-(Piperidin-3-Yloxy)-Pyrazine Hydrochloride is a high-purity pharmaceutical intermediate and research chemical. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily required by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical producers engaged in advanced medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Development & Scale-Up: Serves as a reference standard and starting material for optimizing synthetic routes from laboratory to pilot plant scale.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final molecular structure of target APIs under development.
• Biochemical Research: Employed in studies investigating enzyme inhibition or receptor binding activities due to its specific heterocyclic structure.
• Custom Synthesis & Toll Manufacturing: Supplied to partners requiring bespoke chemical entities for proprietary development pipelines.

Basic Information

Product Name	2-Methyl-3-(Piperidin-3-Yloxy)-Pyrazine Hydrochloride
CAS No.	1420958-13-9
Molecular Formula	C10H16ClN3O
Molecular Weight	229.71 g/mol
Synonyms	2-Methyl-3-(3-piperidinyloxy)pyrazine hydrochloride; 3-((2-Methylpyrazin-3-yl)oxy)piperidine hydrochloride; Pyrazine, 2-methyl-3-(3-piperidinyloxy)-, hydrochloride; 2-Methyl-3-(piperidin-3-yloxy)pyrazine HCl; 1420958-13-9; 3-Piperidinol, 1-((2-methyl-3-pyrazinyl)oxy)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Methyl-3-(Piperidin-3-Yloxy)-Pyrazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and related substances, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.