Description

tert-Butyl 2-(((1,1-Dioxidobenzo[D]Isothiazol-3-Yl)Amino)Methyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel therapeutic agents. This compound is critical for research and development in medicinal chemistry, offering a versatile building block for constructing complex molecules with potential biological activity. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on developing new drugs, particularly in areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly those targeting neurological or inflammatory pathways.
• Medicinal Chemistry Research: Serves as a crucial building block for constructing and screening novel compound libraries in drug discovery programs.
• Protease Inhibitor Development: Used in the synthesis of potential inhibitors, leveraging the benzoisothiazole dioxide (saccharin) moiety as a key pharmacophore.
• Chemical Biology Probes: Employed in the development of tool compounds for studying enzyme function and biological pathways in academic and industrial research settings.
• Custom Synthesis & Scale-Up: Supplied for custom chemical synthesis projects, from milligram-scale research to kilogram-scale process development for clinical trials.

Basic Information

Product Name	tert-Butyl 2-(((1,1-Dioxidobenzo[D]Isothiazol-3-Yl)Amino)Methyl)Piperidine-1-Carboxylate
CAS No.	1420816-42-7
Molecular Formula	C18H25N3O4S
Molecular Weight	379.47 g/mol
Synonyms	1,1-Dioxo-1,2-benzisothiazol-3-amine, N-[[1-[(1,1-dimethylethoxy)carbonyl]-2-piperidinyl]methyl]-; 1-Boc-2-[(1,1-dioxo-1,2-benzisothiazol-3-ylamino)methyl]piperidine; tert-Butyl 2-((1,1-dioxo-1,2-benzisothiazol-3-ylamino)methyl)piperidine-1-carboxylate; 3-[[(1-Boc-2-piperidinyl)methyl]amino]-1,2-benzisothiazole 1,1-dioxide; Saccharin derivative piperidine intermediate; BOC-protected saccharin-piperidine conjugate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(((1,1-Dioxidobenzo[D]Isothiazol-3-Yl)Amino)Methyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants and maintaining an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.