Description

(2S)-2-(8-Amino-1-Bromoimidazo[1,5-A]Pyrazin-3-Yl)-1-Pyrrolidinecarboxylic Acid Phenylmethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a key chiral building block for creating novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology, antiviral, and other specialized drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Medicinal Chemistry Research: Used as a sophisticated building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot and commercial production.
• API Synthesis: Incorporated into the final stages of synthesizing complex, target-specific active pharmaceutical ingredients.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or probes for biochemical and pharmacological assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific molecules.

Basic Information

Product Name	(2S)-2-(8-Amino-1-Bromoimidazo[1,5-A]Pyrazin-3-Yl)-1-Pyrrolidinecarboxylic Acid Phenylmethyl Ester
CAS No.	1420478-88-1
Molecular Formula	C18H17BrN6O2
Molecular Weight	429.27 g/mol
Synonyms	Benzyl (2S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate; (S)-Benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate; 1-Pyrrolidinecarboxylic acid, 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-, phenylmethyl ester, (2S)-; UNII-8J8F2228UJ; 8J8F2228UJ; BDBM50191057; ZINC000253909996; AKOS025147065
EINECS	Contact for details

Quality Control

Every batch of (2S)-2-(8-Amino-1-Bromoimidazo[1,5-A]Pyrazin-3-Yl)-1-Pyrrolidinecarboxylic Acid Phenylmethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and chiral purity essential for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.