Description

(S)-Benzyl 2-(1-Bromo-8-Chloroimidazo[1,5-A]Pyrazin-3-Yl)Pyrrolidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate designed for precision synthesis. This compound is critical for researchers and developers in medicinal chemistry, offering a versatile chiral building block for constructing complex molecular architectures. It is primarily utilized in the research and development of novel therapeutic agents, particularly within the fields of oncology and targeted drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore novel chemical space in drug discovery.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the scale-up and route scouting for potential drug candidates.
• Bioconjugation & Probe Synthesis: The reactive halogenated imidazopyrazine core can be utilized for further functionalization in creating biochemical probes or antibody-drug conjugates (ADCs).
• Academic & Contract Research: Essential for academic laboratories and CROs (Contract Research Organizations) focused on heterocyclic chemistry and novel scaffold development.

Basic Information

Product Name	(S)-Benzyl 2-(1-Bromo-8-Chloroimidazo[1,5-A]Pyrazin-3-Yl)Pyrrolidine-1-Carboxylate
CAS No.	1420478-87-0
Molecular Formula	C18H16BrClN4O2
Molecular Weight	443.70 g/mol
Synonyms	1-Bromo-8-chloro-3-[(2S)-1-(benzyloxycarbonyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazine; (S)-1-((Benzyloxy)carbonyl)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine; Benzyl (2S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate; (S)-Benzyl 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate; CAS 1420478-87-0; 1-Bromo-8-chloro-3-[(S)-1-(Cbz)pyrrolidin-2-yl]imidazo[1,5-a]pyrazine
EINECS	Contact for details

Quality Control

Our (S)-Benzyl 2-(1-Bromo-8-Chloroimidazo[1,5-A]Pyrazin-3-Yl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and chiral purity suitable for demanding research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.