Description

cis-1-((Benzyloxy)Carbonyl)-6-(Trifluoromethyl)Piperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and trifluoromethyl group. This compound is a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily utilized in the research and development of active pharmaceutical ingredients (APIs) within the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• API Development: Used in the process development and scale-up of active pharmaceutical ingredients, leveraging its functional groups for further derivatization.
• Protease Inhibitor Synthesis: Acts as a precursor in the construction of molecules designed to inhibit specific proteases, a common target class in drug discovery.
• Chemical Biology Probes: Employed in the creation of labeled compounds or probes for studying biological pathways and target engagement.

Basic Information

Product Name	cis-1-((Benzyloxy)Carbonyl)-6-(Trifluoromethyl)Piperidine-3-Carboxylic Acid
CAS No.	1419223-39-4
Molecular Formula	C15H16F3NO4
Molecular Weight	331.29 g/mol
Synonyms	1-CBz-6-(trifluoromethyl)piperidine-3-carboxylic acid (cis); (3S,5R)-1-[(Benzyloxy)carbonyl]-5-(trifluoromethyl)piperidine-3-carboxylic acid; (3S,5R)-1-(Benzyloxycarbonyl)-5-(trifluoromethyl)piperidine-3-carboxylic acid; 1-N-CBz-6-Trifluoromethyl-3-piperidinecarboxylic Acid; cis-1-CBz-6-CF3-piperidine-3-carboxylic acid; 1-(Benzyloxycarbonyl)-6-(trifluoromethyl)piperidine-3-carboxylic acid; cis-1-Benzyloxycarbonyl-6-trifluoromethylpiperidine-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our cis-1-((Benzyloxy)Carbonyl)-6-(Trifluoromethyl)Piperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.