Description

cis-4-Aminomethyl-3-Hydroxypiperidine CAS NO 1419101-21-5 is a high-purity, functionalized piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both amino and hydroxyl functional groups on a saturated heterocyclic ring, makes it a versatile intermediate for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands in asymmetric catalysis and metal complex formation.
• Peptidomimetics & Bioisosteres: Incorporated into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	cis-4-Aminomethyl-3-Hydroxypiperidine
CAS No.	1419101-21-5
Molecular Formula	C6H14N2O
Molecular Weight	130.19 g/mol
Synonyms	(3R,4S)-4-(Aminomethyl)piperidin-3-ol; (3R,4S)-4-(Aminomethyl)-3-piperidinol; 4-(Aminomethyl)-3-hydroxypiperidine, cis-; 3-Piperidinol, 4-(aminomethyl)-, (3R,4S)-; cis-4-(Aminomethyl)piperidin-3-ol; 1419101-21-5; (3R,4S)-4-(Aminomethyl)-3-hydroxy-piperidine
EINECS	Contact for details

Quality Control

Our cis-4-Aminomethyl-3-Hydroxypiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.