Description

3-(4-Bromomethyl-Benzenesulfonylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and benzenesulfonylamino functional group. This compound is of critical importance for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Process Development: Serves as a critical starting material or intermediate in the scale-up and optimization of API manufacturing routes under GMP conditions.
• Protease Inhibitor Synthesis: The structural motifs present make it suitable for the development of protease enzyme inhibitors.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	3-(4-Bromomethyl-Benzenesulfonylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1417793-79-3
Molecular Formula	C18H27BrN2O4S
Molecular Weight	447.39 g/mol
Synonyms	1-Boc-3-[(4-(bromomethyl)phenyl)sulfonylamino]piperidine; tert-Butyl 3-[[[4-(bromomethyl)phenyl]sulfonyl]amino]-1-piperidinecarboxylate; 3-[(4-(Bromomethyl)benzenesulfonyl)amino]piperidine-1-carboxylic acid tert-butyl ester; 1-Piperidinecarboxylic acid, 3-[[[4-(bromomethyl)phenyl]sulfonyl]amino]-, 1,1-dimethylethyl ester; N-[(4-(Bromomethyl)phenyl)sulfonyl]-N-(1-Boc-piperidin-3-yl)amine; Boc-3-(4-Bromomethyl-benzenesulfonylamino)-piperidine
EINECS	Contact for details

Quality Control

Our 3-(4-Bromomethyl-Benzenesulfonylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.