Description

(R)-3-(6-Amino-Pyrazin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester CAS NO 1417789-26-4 is a high-purity, chiral piperidine derivative featuring a protected carboxylic acid group and an amino-pyrazine moiety. This compound serves as a critical building block in modern pharmaceutical synthesis, enabling the development of targeted therapeutics. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the production of active pharmaceutical ingredients (APIs) and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Used as a precursor in the research and scale-up manufacturing of new chemical entities (NCEs).
• Process Chemistry & Route Scouting: Employed in the development and optimization of synthetic pathways for more efficient API production.
• Asymmetric Synthesis: Leverages its chiral (R)-piperidine center to introduce stereochemistry into final target molecules.
• Protease Inhibitor Research: The structural motif is relevant in the design of inhibitors for various enzymatic targets.
• Chemical Biology & Probe Development: Serves as a scaffold for creating molecular probes to study biological pathways.

Basic Information

Product Name	(R)-3-(6-Amino-Pyrazin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1417789-26-4
Molecular Formula	C14H22N4O3
Molecular Weight	294.35 g/mol
Synonyms	1-Boc-3-((6-aminopyrazin-2-yl)oxy)-(R)-piperidine; tert-Butyl (R)-3-((6-aminopyrazin-2-yl)oxy)piperidine-1-carboxylate; (R)-1-Boc-3-(6-aminopyrazin-2-yloxy)piperidine; (R)-3-(6-Amino-2-pyrazinyloxy)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; (R)-3-(6-Aminopyrazin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester; BOC-(R)-3-(6-Aminopyrazin-2-yloxy)piperidine; 1417789-26-4
EINECS	Contact for details

Quality Control

Our (R)-3-(6-Amino-Pyrazin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP starting material applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.