Description

cis-(3-Fluoropiperidin-4-Yl)Methanol is a high-value, fluorinated piperidine derivative serving as a crucial chiral building block in advanced organic synthesis. This compound matters for its role in introducing both fluorine and a hydroxymethyl-substituted piperidine scaffold, motifs highly sought after for modulating the physicochemical and pharmacokinetic properties of bioactive molecules. Pharmaceutical and agrochemical research organizations need this intermediate to develop new active ingredients, particularly for central nervous system (CNS) targets, oncology, and other therapeutic areas where fluorine substitution is advantageous.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), especially in neurology and psychiatry.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to explore fluorinated analogs and improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Serves as a building block for developing new generation pesticides and herbicides with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Potential precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for custom synthesis projects requiring specific fluorinated heterocycles.

Basic Information

Product Name	cis-(3-Fluoropiperidin-4-Yl)Methanol
CAS No.	1417789-24-2
Molecular Formula	C6H12FNO
Molecular Weight	133.17 g/mol
Synonyms	4-(Hydroxymethyl)-3-fluoropiperidine, cis- isomer; (3R,4S)-3-Fluoro-4-piperidinemethanol; (3S,4R)-3-Fluoro-4-piperidinemethanol; cis-3-Fluoro-4-piperidinemethanol; 3-Fluoro-4-piperidinemethanol (cis); 4-Piperidinemethanol, 3-fluoro-, cis-; (cis)-3-Fluoropiperidin-4-ylmethanol
EINECS	Contact for details

Quality Control

Our cis-(3-Fluoropiperidin-4-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.