Description

tert-Butyl 2-Ethynylmorpholine-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a morpholine core with a protected carboxylate and an ethynyl functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research and development teams in the pharmaceutical and biotechnology industries for the creation of new drug candidates, particularly in areas like kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) and preclinical drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and introduce alkyne handles for further derivatization.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component due to its ethynyl group, which can be used in click chemistry reactions to assemble bifunctional molecules.
• Kinase Inhibitor Synthesis: Employed in the construction of morpholine-containing scaffolds common in many kinase-targeted therapies.
• Chemical Biology Probes: The alkyne functionality allows for bioorthogonal labeling (e.g., via CuAAC) to study protein interactions and cellular pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	tert-Butyl 2-Ethynylmorpholine-4-Carboxylate
CAS No.	1416229-07-6
Molecular Formula	C11H17NO3
Molecular Weight	211.26 g/mol
Synonyms	4-(tert-Butoxycarbonyl)-2-ethynylmorpholine; 2-Ethynylmorpholine-4-carboxylic acid tert-butyl ester; tert-Butyl 2-ethynyl-4-morpholinecarboxylate; 2-Ethynyl-4-morpholinecarboxylic acid 1,1-dimethylethyl ester; 2-Ethynylmorpholine-4-carboxylate tert-butyl ester; BOC-2-ethynylmorpholine; N-Boc-2-ethynylmorpholine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Ethynylmorpholine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. For projects requiring specific documentation, we can support with additional data packages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.