Description

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine is a high-value, synthetically versatile organoboron building block, specifically a pyridine-substituted pinacol boronic ester. This compound matters as a critical intermediate in modern cross-coupling reactions, enabling the precise construction of complex molecules for advanced research and development. It is primarily needed by pharmaceutical, agrochemical, and advanced materials chemists for applications in drug discovery, ligand synthesis, and the creation of functional organic frameworks.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced properties.
• Ligand & Catalyst Development: Serves as a precursor for creating sophisticated nitrogen-containing ligands used in catalysis and material science.
• Organic Electronic Materials: Employed in the synthesis of conjugated polymers and small molecules for OLEDs, OFETs, and other optoelectronic devices.
• Chemical Biology & Probe Synthesis: Useful for labeling and modifying biomolecules or creating fluorescent probes for diagnostic applications.
• Academic & Industrial R&D: A fundamental reagent for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine
CAS No.	1415748-20-7
Molecular Formula	C13H17BF3NO3
Molecular Weight	303.09 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(Pinacolatoboryl)-2-(2,2,2-trifluoroethoxy)pyridine; 2-(Trifluoroethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoroethoxy)pyridine; Pyridine, 2-(2,2,2-trifluoroethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; B-2-(2,2,2-Trifluoroethoxy)-4-pyridinylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.