Description

Methyl 3-(5-Chloro-2-Fluorobenzamido)Pyrazine-2-Carboxylate is a structurally complex, heteroaromatic amide derivative featuring chloro-fluoro substituted benzamide and pyrazine carboxylate motifs. This compound serves as a high-value advanced intermediate in the synthesis of novel pharmaceutical agents—particularly kinase inhibitors and antimicrobial candidates—where precise halogen positioning enables optimized target binding and metabolic stability. It is primarily utilized by R&D laboratories and API manufacturers engaged in oncology, anti-infective, and CNS drug discovery programs. Methyl 3-(5-Chloro-2-Fluorobenzamido)Pyrazine-2-Carboxylate CAS NO 1415559-90-8 is supplied under stringent quality controls to support reproducible process development and regulatory submissions.

Application

• Key synthetic intermediate in the preparation of investigational tyrosine kinase inhibitors (TKIs) for solid tumor therapies
• Building block for fluorinated pyrazine-based antimicrobial scaffolds targeting resistant Gram-negative pathogens
• Chemical probe for structure–activity relationship (SAR) studies in bromodomain and extra-terminal (BET) protein inhibitor programs
• Custom synthesis substrate for contract research organizations (CROs) developing next-generation antiviral agents
• Reference standard in analytical method development and validation for LC-MS/MS quantification in biological matrices
• Material for solid-phase peptide coupling strategies requiring orthogonal amide bond formation with electron-deficient heterocycles

Basic Information

Product Name	Methyl 3-(5-Chloro-2-Fluorobenzamido)Pyrazine-2-Carboxylate
CAS No.	1415559-90-8
Molecular Formula	C14H9ClFN3O2
Molecular Weight	305.69 g/mol
Synonyms	3-(5-Chloro-2-fluorobenzamido)pyrazine-2-carboxylic acid methyl ester; Methyl 3-[(5-chloro-2-fluorophenyl)carbamoyl]pyrazine-2-carboxylate; MFCD28979127; Pyrazine-2-carboxylic acid, 3-[(5-chloro-2-fluorophenyl)amino]-, methyl ester; 1415559-90-8 (CAS); Methyl 3-(5-chloro-2-fluorobenzoylamino)pyrazine-2-carboxylate; NSC 900238; T3D5485
EINECS	Not listed (not yet assigned)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, HPLC retention time), purity (≥98.5% by HPLC), and absence of critical impurities (residual solvents, heavy metals, and genotoxic nitrosamine precursors). Manufacturing adheres to ISO 9001-certified processes, and documentation supports ICH Q5, Q7, and FDA 21 CFR Part 211 requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area. Keep away from strong acids, organic solvents, fluoride sources, and strong alkalis. Avoid exposure to moisture and oxygen—recommended under inert atmosphere (nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identity (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Single impurity ≤0.3%; Total impurities ≤1.0%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Heavy Metals (as Pb)	≤10 ppm
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.