Description

Mk8245 Trifluoroacetate is a high-purity, fluorinated small-molecule intermediate widely used in pharmaceutical and agrochemical synthesis. Its trifluoroacetate salt form enhances solubility and stability during coupling reactions, making it critical for constructing complex bioactive molecules. This compound is essential for R&D laboratories and contract manufacturing organizations (CMOs) developing kinase inhibitors, GPCR modulators, and novel crop protection agents. Mk8245 Trifluoroacetate CAS NO 1415559-41-9 is supplied under strict quality controls to ensure batch-to-batch reproducibility and regulatory compliance.

Application

• Key synthetic intermediate in the manufacture of investigational oncology drugs (e.g., selective CDK2/4/6 inhibitors)
• Coupling reagent in peptide mimetic synthesis for metabolic disease therapeutics
• Building block for fluorinated heterocyclic scaffolds in next-generation fungicides and herbicides
• Chiral auxiliary support in asymmetric catalysis for enantioselective C–F bond formation
• Stabilized precursor in solid-phase synthesis of PROTACs (Proteolysis-Targeting Chimeras)
• Reference standard for LC-MS/MS method development in bioanalytical laboratories

Basic Information

Product Name	Mk8245 Trifluoroacetate
CAS No.	1415559-41-9
Molecular Formula	C17H14F3N3O3·C2F3O2
Molecular Weight	461.35 g/mol
Synonyms	MK-8245 TFA; MK8245 trifluoroacetic acid salt; (S)-N-(1-(3-(Trifluoromethyl)phenyl)ethyl)-2-(methylamino)pyrimidine-5-carboxamide trifluoroacetate; MK8245-TFA; MK-8245 trifluoroacetate; CAS 1415559-41-9; Trifluoroacetate salt of MK-8245; MK8245•TFA
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q2(R2) guidelines for identification, assay, residual solvents, heavy metals, and related substances. Testing includes HPLC purity ≥99.5%, water content by Karl Fischer ≤0.5%, and residual TFA ≤0.3% w/w. Manufactured under ISO 9001-certified processes with full traceability from raw material sourcing to final packaging.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity. Avoid repeated opening of containers and use desiccated storage conditions where possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥99.5%
Related Substances	≤0.5% total impurities
Residual Solvents (by GC)	Meets ICH Q3C limits
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Trifluoroacetic Acid	≤0.3% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.