Description

H2N-PEG12-CH2CH2COOH is a heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine and a carboxylic acid group, separated by a flexible 12-unit PEG spacer. This compound is essential for creating stable, hydrophilic linkers in bioconjugation and drug delivery systems, enabling the coupling of biomolecules with minimal steric hindrance. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing targeted therapeutics, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation Reagent: For linking peptides, proteins, antibodies, or oligonucleotides to surfaces, nanoparticles, or other molecules via its amine and carboxyl reactive ends.
• Drug Delivery System Component: As a key building block in the synthesis of antibody-drug conjugates (ADCs), PEGylated drugs, and prodrugs to enhance solubility and circulation time.
• Crosslinker for Hydrogel Formation: Used in the development of biocompatible hydrogels for tissue engineering and controlled release applications.
• Surface Functionalization: For modifying gold nanoparticles, quantum dots, or other nanomaterials to introduce specific chemical handles for further coupling.
• Diagnostic Assay Development: In the fabrication of biosensors and immunoassay platforms by attaching capture molecules to solid supports.
• Polymer Chemistry Intermediate: Serves as a monomer or macromonomer for synthesizing functional, water-soluble copolymers.

Basic Information

Product Name	H2N-PEG12-CH2CH2COOH
CAS No.	1415408-69-3
Molecular Formula	C31H63NO15
Molecular Weight	689.8 g/mol
Synonyms	15-Amino-4,7,10,13-tetraoxa-3-azahexadecan-1-oic acid, 3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxa-2,37-diazaheptatetracontanedioic acid; Amino-PEG12-acetic acid; α-Amino-ω-carboxy PEG12; Amine-PEG12-COOH; NH2-PEG12-COOH; 15-Amino-4,7,10,13-tetraoxapentadecanoic acid (PEGylated form); Heterobifunctional PEG12 linker
EINECS	Contact for details

Quality Control

Our H2N-PEG12-CH2CH2COOH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Functional Groups)	≥ 90% (Amino & Carboxyl)
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.