Description

3-Aza-Bicyclo[4.1.0]Heptane Hydrochloride is a high-purity, nitrogen-containing bicyclic organic compound supplied as a hydrochloride salt. This versatile building block is critical for pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and complex molecular scaffolds. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce constrained amine motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) targeted drugs, enzyme inhibitors, and receptor modulators.
• Medicinal Chemistry: Used as a rigid, sp3-rich amine scaffold in fragment-based drug discovery and lead optimization programs to improve metabolic stability and binding affinity.
• Agrochemical Synthesis: Serves as a precursor in the creation of novel herbicides, fungicides, and insecticides with unique modes of action.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and molecular probes for studying biological pathways and protein function.
• Asymmetric Catalysis: Potential use as a chiral ligand or catalyst precursor in stereoselective synthesis.
• Academic Research: Fundamental research in organic methodology development and the exploration of new chemical space.

Basic Information

Product Name	3-Aza-Bicyclo[4.1.0]Heptane Hydrochloride
CAS No.	1414958-74-9
Molecular Formula	C6H12ClN
Molecular Weight	133.62 g/mol
Synonyms	3-Azabicyclo[4.1.0]heptane hydrochloride; 1-Aza-4-methylenebicyclo[3.1.0]hexane hydrochloride; 3-Azabicyclo[4.1.0]heptane, hydrochloride; Bicyclo[4.1.0]heptane, 3-aza-, hydrochloride; 3-Azabicyclo[4.1.0]heptane HCl; 3-Aza-bicyclo[4.1.0]heptane monohydrochloride
EINECS	Contact for details

Quality Control

Our 3-Aza-Bicyclo[4.1.0]Heptane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) documenting full specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.