Description

2-Cyclopropyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazine is a high-value pyrazine-based boronic ester building block, essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, to construct complex molecular architectures with precision. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex heterocyclic cores.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	2-Cyclopropyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazine
CAS No.	1412905-41-9
Molecular Formula	C13H19BN2O2
Molecular Weight	246.11 g/mol
Synonyms	2-Cyclopropyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; 6-Cyclopropyl-3-pyrazinylboronic acid pinacol ester; 2-(6-Cyclopropylpyrazin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 6-Cyclopropylpyrazine-2-boronic acid pinacol ester; Pyrazine, 2-cyclopropyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; B-(6-Cyclopropyl-2-pyrazinyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.