Description

3-(Benzyloxy)-5-Chloro-2-Iodopyrazine is a high-purity, multi-functional halogenated pyrazine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique molecular scaffold, which combines a reactive iodo substituent with a benzyl-protected oxygen, enabling precise functionalization for complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the pyrazine core for bioactivity.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form new carbon-carbon bonds.
• Chemical Biology: Employed as a probe or labeling reagent due to its reactive halogen site for bioconjugation strategies.
• Academic & Contract Research: A valuable tool for synthetic methodology development and exploring new chemical spaces in academic and industrial R&D laboratories.

Basic Information

Product Name	3-(Benzyloxy)-5-Chloro-2-Iodopyrazine
CAS No.	1410164-82-7
Molecular Formula	C11H8ClIN2O
Molecular Weight	346.55 g/mol
Synonyms	5-Chloro-3-(phenylmethoxy)-2-iodopyrazine; 2-Iodo-5-chloro-3-benzyloxypyrazine; 3-Benzyloxy-5-chloro-2-iodopyrazine; 1410164-82-7; 5-Chloro-2-iodo-3-(benzyloxy)pyrazine; Pyrazine, 5-chloro-3-(phenylmethoxy)-2-iodo-; 3-(Benzyloxy)-5-chloro-2-iodopyrazine
EINECS	Contact for details

Quality Control

Every batch of 3-(Benzyloxy)-5-Chloro-2-Iodopyrazine is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.