Description

1-Pyrrolidinecarboxylic Acid, 4-[4-(3-Methyl-1-Phenyl-1H-Pyrazol-5-Yl)-1-Piperazinyl]-2-(3-Thiazolidinylcarbonyl)-, 1,1-Dimethylethyl Ester, (2S,4R)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting specific biological pathways. Pharmaceutical R&D and manufacturing organizations need this material for developing and scaling up novel therapeutic agents, where its precise stereochemistry and purity are essential for ensuring final product efficacy and regulatory compliance.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, small-molecule drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Protease Inhibitor Research: Used in the research and development of protease inhibitors, leveraging its complex heterocyclic and peptidomimetic structure.
• Chemical Biology Probes: Serves as a precursor for creating specialized chemical probes to study enzyme function and intracellular signaling pathways.
• Peptidomimetic Scaffold: Provides a sophisticated scaffold for medicinal chemistry programs aimed at improving metabolic stability and bioavailability of peptide-based drugs.
• Process Chemistry & Scale-Up: Employed in process development and optimization for the commercial-scale manufacturing of target APIs.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) performing bespoke synthesis for client projects.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 4-[4-(3-Methyl-1-Phenyl-1H-Pyrazol-5-Yl)-1-Piperazinyl]-2-(3-Thiazolidinylcarbonyl)-, 1,1-Dimethylethyl Ester, (2S,4R)-
CAS No.	1404559-22-3
Molecular Formula	C28H38N6O3S
Molecular Weight	538.71 g/mol
Synonyms	(2S,4R)-tert-Butyl 4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate; (2S,4R)-1-Boc-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)pyrrolidine; tert-Butyl (2S,4R)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate; 1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)-; (2S,4R)-1-(tert-Butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(thiazolidine-3-carbonyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 4-[4-(3-Methyl-1-Phenyl-1H-Pyrazol-5-Yl)-1-Piperazinyl]-2-(3-Thiazolidinylcarbonyl)-, 1,1-Dimethylethyl Ester, (2S,4R)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2S,4R)-isomer
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.