Description

Teneligliptin (2R,4R)-Isomer is a high-purity stereoisomer of the dipeptidyl peptidase-4 (DPP-4) inhibitor Teneligliptin, a key active pharmaceutical ingredient (API) used in the treatment of type 2 diabetes. This specific isomer is critical for ensuring the desired pharmacological activity and minimizing potential side effects, making it an essential building block for pharmaceutical development and manufacturing. It is primarily required by pharmaceutical companies and research institutions engaged in the synthesis of high-efficacy antidiabetic drugs and advanced metabolic disorder research.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as the core chiral intermediate in the commercial production of Teneligliptin hemihydrate, the finished drug substance.
• Pharmaceutical Research & Development (R&D): Used in preclinical and clinical studies to investigate the efficacy and safety profile of the specific (2R,4R) stereoisomer.
• Process Chemistry & Optimization: Employed in developing and scaling up efficient, stereoselective synthetic routes for DPP-4 inhibitors.
• Reference Standard: Acts as a high-purity chemical reference standard for quality control (QC) and analytical method development in pharmaceutical laboratories.
• Metabolic Disease Research: Utilized in biochemical assays and studies targeting the DPP-4 enzyme pathway to explore new therapeutic avenues for diabetes.

Basic Information

Product Name	Teneligliptin (2R,4R)-Isomer
CAS No.	1404559-17-6
Molecular Formula	C22H30N6O2S
Molecular Weight	442.58 g/mol
Synonyms	(2R,4R)-Teneligliptin; (2R,4R)-4-[(3S)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(1,3-thiazolidin-3-yl)-1-piperidinecarboxylic acid 2,2,2-trifluoroethyl ester; (2R,4R)-Isomer of Teneligliptin; Teneligliptin Intermediate; DPP-4 Inhibitor Intermediate; BRX-0585 (2R,4R)-Isomer
EINECS	Contact for details

Quality Control

Our Teneligliptin (2R,4R)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for stereochemical purity, to ensure it meets stringent specifications suitable for pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,4R)-Isomer
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.