Description

(2S,4R)-Teneligliptin CAS NO 1404559-15-4 is a high-purity, stereochemically defined active pharmaceutical ingredient (API) belonging to the dipeptidyl peptidase-4 (DPP-4) inhibitor class. This compound is critical for the development and manufacturing of advanced antidiabetic medications, offering a targeted mechanism of action for glycemic control. Pharmaceutical manufacturers and research institutions engaged in metabolic disorder therapeutics require this specific enantiomer to ensure drug efficacy and regulatory compliance.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of oral antidiabetic drugs for Type 2 Diabetes Mellitus (T2DM) treatment.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation of teneligliptin-based products.
• Clinical Research: Serves as a key intermediate or final compound in preclinical and clinical studies investigating new diabetes therapies and combination treatments.
• Drug Development: Essential for process chemistry development, stability studies, and formulation research for novel DPP-4 inhibitor medications.
• Generic Drug Manufacturing: Used by generic pharmaceutical companies to produce bioequivalent versions of teneligliptin after patent expiry.

Basic Information

Product Name	(2S,4R)-Teneligliptin
CAS No.	1404559-15-4
Molecular Formula	C22H30N6O2S
Molecular Weight	442.58 g/mol
Synonyms	Teneligliptin; Teneligliptin Hydrobromide Hydrate (common salt form); (2S,4S)-4-(4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine; TNP-2092; BR-A-657; DPP-4 Inhibitor Teneligliptin; (2S,4R)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(1-pyrrolidinylcarbonyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (2S,4R)-Teneligliptin is manufactured under strict quality management systems, targeting standards suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure identity, potency, and impurity profile compliance. A Certificate of Analysis (COA) detailing specific results for assay, enantiomeric excess, related substances, residual solvents, and heavy metals is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation. The original container should be kept sealed in a desiccated environment after each use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.