Description

1-Piperazinecarboxylic Acid, 2-Methyl-5-[[(3R)-3-Methyl-4-Morpholinyl]Methyl]-4-(Phenylmethyl)-, 1,1-Dimethylethyl Ester, (2R,5S)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex stereochemistry and functional groups. This compound is of critical importance for the synthesis of sophisticated active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development and production of new chemical entities (NCEs) and complex generic drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex, high-value active pharmaceutical ingredients (APIs).
• Drug Discovery & Development: Used in medicinal chemistry research for the construction of novel molecular scaffolds during lead optimization and candidate selection.
• Process Chemistry: Employed in the scale-up and commercial route development for new therapeutic agents, benefiting from its defined stereochemistry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial API batches.
• Protease Inhibitor Synthesis: May serve as a precursor or intermediate in the synthesis of protease inhibitor类药物, given its structural motifs.
• Chemical Biology Research: Utilized as a tool compound or a precursor for labeled probes in biochemical and pharmacological studies.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 2-Methyl-5-[[(3R)-3-Methyl-4-Morpholinyl]Methyl]-4-(Phenylmethyl)-, 1,1-Dimethylethyl Ester, (2R,5S)-
CAS No.	1403902-77-1
Molecular Formula	C24H39N3O3
Molecular Weight	417.59 g/mol
Synonyms	(2R,5S)-tert-Butyl 2-methyl-4-benzyl-5-((R)-3-methylmorpholino)methyl)piperazine-1-carboxylate; (2R,5S)-2-Methyl-5-[[(3R)-3-methyl-4-morpholinyl]methyl]-4-(phenylmethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl (2R,5S)-2-methyl-4-benzyl-5-(((R)-3-methylmorpholino)methyl)piperazine-1-carboxylate; UNII-9Q6Q9N6N8I; 9Q6Q9N6N8I; (2R,5S)-Boc-2-methyl-4-benzyl-5-((R)-3-methylmorpholino)methyl)piperazine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. We employ advanced analytical techniques including HPLC, GC, and NMR to verify identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, detailing batch-specific results for all critical quality attributes. Our quality management system supports the stringent requirements of cGMP (current Good Manufacturing Practice) for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.