Description

(2R,5R)-tert-Butyl 5-(Hydroxymethyl)-2-Methylpiperazine-1-Carboxylate is a high-purity, chiral piperazine derivative serving as a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, enabling the development of targeted therapeutics with enhanced efficacy and reduced side effects. This compound is essential for R&D and production teams in the pharmaceutical and biotechnology industries, particularly those focused on developing novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly for novel small molecule therapies.
• API Development: Used as a core structural component in the research and development of new Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce specific chiral centers into target molecules, crucial for producing enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Peptidomimetics & PROTACs: Utilized in the design and synthesis of peptidomimetic compounds and Proteolysis Targeting Chimeras (PROTACs) due to its piperazine backbone and functional handles.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) offering custom synthesis services for clinical trial materials.

Basic Information

Product Name	(2R,5R)-tert-Butyl 5-(Hydroxymethyl)-2-Methylpiperazine-1-Carboxylate
CAS No.	1403898-64-5
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	1-Boc-(2R,5R)-5-(Hydroxymethyl)-2-methylpiperazine; tert-Butyl (2R,5R)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate; (2R,5R)-1-N-Boc-5-(Hydroxymethyl)-2-methylpiperazine; (2R,5R)-1-(tert-Butoxycarbonyl)-5-(hydroxymethyl)-2-methylpiperazine; Boc-(2R,5R)-5-Hydroxymethyl-2-methylpiperazine; (2R,5R)-5-Hydroxymethyl-2-methylpiperazine-1-carboxylic acid tert-butyl ester; (2R,5R)-2-Methyl-5-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (2R,5R)-tert-Butyl 5-(Hydroxymethyl)-2-Methylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.