Description

((2R,5R)-5-Methylpiperazin-2-Yl)Methanol Hcl CAS NO 1403898-63-4 is a high-purity chiral piperazine derivative, a critical building block in modern pharmaceutical synthesis. Its primary value lies in its defined stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs) with targeted biological activity and reduced side-effect profiles. This compound is specifically needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, especially protease inhibitors and other enzyme-targeted therapies.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component for new chemical entities (NCEs) in preclinical and clinical research.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand in catalytic processes to induce stereoselectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties of lead compounds.
• Bioconjugation & Prodrug Design: The functional groups allow for conjugation to targeting moieties or the creation of prodrug formulations.
• Chemical Biology Probes: Used to develop molecular probes for studying biological pathways and target validation.

Basic Information

Product Name	((2R,5R)-5-Methylpiperazin-2-Yl)Methanol Hydrochloride
CAS No.	1403898-63-4
Molecular Formula	C6H15ClN2O
Molecular Weight	166.65 g/mol
Synonyms	(2R,5R)-5-Methyl-2-piperazinemethanol hydrochloride; (2R,5R)-5-Methylpiperazine-2-methanol HCl; (2R,5R)-1,4-Diazacyclohexane-2-methanol, 5-methyl-, hydrochloride; (2R,5R)-5-Methyl-2-(hydroxymethyl)piperazine hydrochloride; (2R,5R)-5-Methyl-2-piperazinmethanol hydrochloride; (2R,5R)-5-Methyl-2-(hydroxymethyl)piperazine HCl; (2R,5R)-5-Methyl-2-piperazinylmethanol hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are available upon request, detailing specifications such as chiral purity (enantiomeric excess), chemical purity (HPLC), and residual solvent content. We adhere to cGMP principles for pharmaceutical intermediates to ensure supply chain reliability and data integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.