Description

4-(Azetidin-3-Yl)Piperazin-2-One Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1403766-88-0. This compound is a critical building block in modern medicinal chemistry, valued for its azetidine-piperazinone core which is instrumental in modulating biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the synthesis of heterobifunctional molecules designed for targeted protein degradation.
• Kinase Inhibitor Synthesis: A crucial component in the synthesis pathway of small molecule inhibitors targeting various kinases.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery and development projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	4-(Azetidin-3-Yl)Piperazin-2-One Dihydrochloride
CAS No.	1403766-88-0
Molecular Formula	C7H14N3O•2HCl
Molecular Weight	239.13 g/mol (Free base: 168.21)
Synonyms	4-(Azetidin-3-yl)piperazin-2-one dihydrochloride; 2-Piperazinone, 4-(3-azetidinyl)-, dihydrochloride; 4-(3-Azetidinyl)-2-piperazinone dihydrochloride; 1-(Azetidin-3-yl)piperazin-2-one dihydrochloride; Azetidine-piperazinone dihydrochloride intermediate; CAS 1403766-88-0
EINECS	Contact for details

Quality Control

Every batch of 4-(Azetidin-3-Yl)Piperazin-2-One Dihydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development applications, with Certificates of Analysis (COA) provided for each lot, detailing key parameters such as assay and impurity profiles. We adhere to industry best practices to support your critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.