Description

1-(3-Chloro-Pyrazin-2-Yl)-Piperidine-4-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with the CAS number 1400645-27-3. This compound is a critical building block in modern medicinal chemistry, valued for its unique heterocyclic structure that enables the synthesis of complex, bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Serves as a core structural component in the creation of potential kinase inhibitors for targeted cancer therapies.
• CNS Drug Candidates: Employed in the research and development of compounds targeting neurological disorders.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	1-(3-Chloro-Pyrazin-2-Yl)-Piperidine-4-Carboxylic Acid Methyl Ester
CAS No.	1400645-27-3
Molecular Formula	C11H14ClN3O2
Molecular Weight	255.70 g/mol
Synonyms	Methyl 1-(3-chloropyrazin-2-yl)piperidine-4-carboxylate; 1-(3-Chloro-2-pyrazinyl)-4-piperidinecarboxylic acid methyl ester; 4-Piperidinecarboxylic acid, 1-(3-chloro-2-pyrazinyl)-, methyl ester; 1400645-27-3; Methyl 1-(3-chloro-2-pyrazinyl)piperidine-4-carboxylate; 1-(3-Chloro-pyrazin-2-yl)-piperidine-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 1-(3-Chloro-Pyrazin-2-Yl)-Piperidine-4-Carboxylic Acid Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.