Description

trans-Methyl 1-Benzyl-4-((tert-Butoxycarbonyl)Amino)Piperidine-3-Carboxylate CAS NO 1398504-06-7 is a high-purity, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Peptidomimetic Synthesis: The protected amino and ester functionalities make it valuable for constructing non-peptide analogs that mimic peptide bioactivity.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries focused on piperidine-based pharmacophores.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce complex chiral centers into target molecules.

Basic Information

Product Name	trans-Methyl 1-Benzyl-4-((tert-Butoxycarbonyl)Amino)Piperidine-3-Carboxylate
CAS No.	1398504-06-7
Molecular Formula	C20H30N2O4
Molecular Weight	362.47 g/mol
Synonyms	trans-Methyl 1-benzyl-4-[(tert-butoxycarbonyl)amino]piperidine-3-carboxylate; (3R,4S)-Methyl 1-benzyl-4-((tert-butoxycarbonyl)amino)piperidine-3-carboxylate; (3S,4R)-Methyl 1-benzyl-4-((tert-butoxycarbonyl)amino)piperidine-3-carboxylate; trans-1-Benzyl-4-((Boc)amino)piperidine-3-carboxylic acid methyl ester; trans-1-Benzyl-4-(Boc-amino)piperidine-3-carboxylic acid methyl ester; Methyl (3R,4S)-1-benzyl-4-{[(tert-butoxy)carbonyl]amino}piperidine-3-carboxylate; Boc-4-amino-1-benzyl-piperidine-3-carboxylic acid methyl ester (trans); 1398504-06-7
EINECS	Contact for details

Quality Control

Our trans-Methyl 1-Benzyl-4-((tert-Butoxycarbonyl)Amino)Piperidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.