Description

2-(2-Bromo-6-Fluorophenyl)-1,3-Dioxolane is a high-purity fluorinated and brominated aromatic building block, specifically designed for advanced synthetic chemistry. Its unique structure, featuring both halogen substituents and a protected aldehyde functionality, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on the synthesis of novel active ingredients, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated aromatic compounds.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic core.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille), enabling rapid diversification of molecular scaffolds.
• Protecting Group Chemistry: The 1,3-dioxolane moiety acts as a protecting group for aldehydes, allowing for selective reactions at other sites on the molecule before deprotection.

Basic Information

Product Name	2-(2-Bromo-6-Fluorophenyl)-1,3-Dioxolane
CAS No.	1394824-55-5
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	1,3-Dioxolane, 2-(2-bromo-6-fluorophenyl)-; 2-(2-Bromo-6-fluorophenyl)-1,3-dioxolane; 2-Bromo-6-fluorobenzaldehyde ethylene acetal; (2-Bromo-6-fluorophenyl)-1,3-dioxolane; Benzaldehyde, 2-bromo-6-fluoro-, ethylene acetal; 2-(2-Bromo-6-fluoro-phenyl)-[1,3]dioxolane
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Bromo-6-Fluorophenyl)-1,3-Dioxolane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.