Description

(2S)-2-(Trifluoromethyl)Morpholine CAS NO 1393524-24-7 is a high-value, chiral morpholine derivative distinguished by the presence of a trifluoromethyl group, a key structural motif that imparts unique physicochemical properties. This compound is a critical chiral building block and intermediate in modern synthetic chemistry, particularly valued for its ability to modulate the metabolic stability, lipophilicity, and bioavailability of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) drugs, antivirals, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and electronic materials that benefit from fluorine-containing moieties.
• Chemical Biology & Medicinal Chemistry: Utilized as a probe or building block in drug discovery programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	(2S)-2-(Trifluoromethyl)Morpholine
CAS No.	1393524-24-7
Molecular Formula	C5H8F3NO
Molecular Weight	155.12 g/mol
Synonyms	(S)-2-(Trifluoromethyl)morpholine; (2S)-2-(Trifluoromethyl)-1,4-oxazinane; Morpholine, 2-(trifluoromethyl)-, (2S)-; (S)-2-Trifluoromethylmorpholine; (S)-2-(Trifluoromethyl)tetrahydro-1,4-oxazine; (S)-α-(Trifluoromethyl)morpholine; (S)-2-(Trifluoromethyl)-1,4-oxazine
EINECS	Contact for details

Quality Control

Our (2S)-2-(Trifluoromethyl)Morpholine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis (HPLC/GC), identity confirmation (IR, NMR), and impurity profiling to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and all relevant specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain purity and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.